Excessive consumption of goat meat can increase the risk of blockage of blood vessels which causes heart disease and stroke, this is due to the high cholesterol content. This study aims to determine the effect of applying fresh noni leaves in reducing cholesterol, LDL (Low Density Lipoprotein), HDL (High Densiy Lippoprotein) and TG (Tryglicerida) in goat blood. The research was conducted in an experimental cage in Tatura Village, South Palu District, Palu City and Central Sulawesi Health Laboratory, from August to September 2019. Using two groups i.e., 6 were given fresh noni leaves and 6 were given king grass + corn leaves. The variables to be observed were total cholesterol, LDL, HDL and TG content in goat blood, which were analyzed using the CHOD-PAP photometric method. The use of fresh noni leaves to goats during the study (4 weeks) significantly reduced the total cholesterol (TKL), LDL and HDL content compared to those which had been given king grass + corn leaves (P < 0.01), while the TG content showed no significant difference (P>0.05). Giving fresh noni leaves to etawa crossbread goats can be used to reduce total cholesterol, LDL and HDL and increase TG.